New study pinpoints how immune checkpoint protein LAG3 modulates T cell activity
Fighting cancer and chronic disease is tiring work for the immune system. When T cells are engaged in this kind of lengthy battle, they can...
Immunology
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New insight into lymphoid cell maturity could pave the way for more effective IBD treatments
A research group at Karolinska Institutet in Sweden has analyzed how certain immune cells known as innate lymphoid cells (ILCs) develop into mature cells that...
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A comprehensive rule book for the design of safe and efficient therapeutic cells
Therapies based on engineered immune cells have recently emerged as a promising approach in the treatment of cancer. Compared to traditional drugs, engineered immune cells...
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Breakthrough finding reveals how male sex hormones contribute to cancer-related sex bias
Patients with cancers stemming from non-reproductive organs, such as bladder and liver cancer, have striking discrepancies in incidence, progression, response to treatment and survival outcomes...
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Researchers track COVID-fighting antibodies after vaccination
The antibodies generated by Pfizer’s COVID-19 vaccine rise more slowly and decline more quickly than those generated by the Moderna vaccine, according to a new...
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Zika virus can mutate to become more infective and dangerous, finds study
Researchers at La Jolla Institute for Immunology (LJI) have found that Zika virus can mutate to become more infective-;and potentially break through pre-existing immunity. “The...
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Researchers elucidate how ovarian tumors defy immunotherapy
Researchers at University of California San Diego School of Medicine and Moores Cancer Center at UC San Diego Health, with collaborators at La Jolla Institute...
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Safety, reactogenicity, and immunogenicity of the BNT and half-m1273 mRNA COVID-19 vaccines given as a fourth dose booster
In a recent study posted to Preprints with The Lancet*, researchers evaluated the immunogenicity of Pfizer’s BNT162b2 and Moderna’s messenger ribonucleic acid (mRNA-1273) vaccines offered...
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A critical subset of supporting cells may lie at the origins of rare autoimmune disease
Supporting actors sometimes steal the show. In a new study published today in Cell, researchers headed by Prof. Ido Amit at the Weizmann Institute of...
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Key protein could be a novel target for treatment of patients with B cell signaling deficiencies
The rules to the kids’ game “red light, green light” are easy to follow: red always means stop, and green always means go. But now,...
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Tulane researchers show how COVID-19 affects the central nervous system
COVID-19 patients commonly report having headaches, confusion and other neurological symptoms, but doctors don’t fully understand how the disease targets the brain during infection. Now,...
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NIH program provides a real-time risk assessment of variants of SARS-CoV-2
Faculty from the Departments of Microbiology, Medicine Genetics and Genomic Sciences, and Pathology and Molecular Cell-Based Medicine at the Icahn School of Medicine at Mount...