New NIH-funded research to solve the male infertility and spermatogenesis puzzle
Male infertility is on the rise, with significant declines in sperm quantity and quality occurring across the human population worldwide in the past two decades....
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Researchers supplement synthetic biology toolkit to streamline investigations into genetic code expansion
One of modern biologists’ most ambitious goals is to learn how to expand or otherwise modify the genetic code of life on Earth, in order...
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Assay for the sensitive and specific identification of SARS-CoV-2 Delta variant
The Delta variant (B.1.617.2) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first detected in India and is currently replacing the variants circulating in...
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The ability of natural flavonoids to inhibit SARS-CoV-2
A recent systematic review discusses naturally occurring flavonoids as a promising antiviral alternative against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Moreover, this review...
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Xanthohumol as a potent pan-inhibitor for various coronaviruses
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel coronavirus infecting humans and livestock worldwide. Not all coronavirus infections cause major symptoms but some...
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IFITM proteins are important replication cofactors for SARS-CoV-2, including Delta variant
The causative agent responsible for the unprecedented coronavirus disease 2019 (COVID-19) pandemic is severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The mechanism of entry of...
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SARS-CoV-2 ORF10 degrades mitochondrial antiviral signaling protein to suppress immune response
Coronaviruses (CoVs) infect humans, pigs, cattle, horses, rats, and bats, among other host species. These viruses mainly cause infections of the respiratory and digestive tracts,...
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SARS-CoV-2 VOCs dependent on IFITM2 for efficient infection establishment
Interferon-inducible transmembrane proteins (IFITMs), including IFITMs 1, 2, and 3, are well-known for their inhibitory effects against numerous viral pathogens including the highly pathogenic severe...
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Small molecule identified as a SARS-CoV-2 inhibitor
The coronavirus disease 2019 (COVID-19) pandemic is caused by the beta-coronavirus termed the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Its rapid and extensive...
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SARS-CoV-2 Omicron has similar infectious viral load to Delta
In a recent study published on the medRxiv* preprint server, researchers compare severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pre-variants of concern (VOC) strains and...
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Development of synthetic molecules that can bridge T cells with SARS-CoV-2 infected cells
The coronavirus disease 2019 (COVID-19) pandemic has been caused by a rapid outbreak of a novel RNA virus, namely, severe acute respiratory syndrome coronavirus-2...
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Genome study reveals unexpected heterogeneity of human ribosomal RNA genes
A genome study undertaken by Johns Hopkins Kimmel Cancer Center researchers to look for variants in a gene considered a fundamental building block for microscopic...