The challenges of Omicron
The coronavirus disease 2019 (COVID-19) pandemic broke out early in 2020, following the reporting of several cases of pneumonia caused by the severe acute respiratory...
Antigen
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Heterologous booster dose leads to better SARS-CoV-2 vaccine performance, study shows
A new study on Chile’s national COVID-19 vaccination program, to be presented at this year’s European Congress of Clinical Microbiology & Infectious Diseases (ECCMID 2022,...
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Less PSA testing minimizes overdiagnosis but may lead to increase in metastatic prostate cancer cases
Over the past 15 years, public health authorities have downgraded recommendations for the prostate-specific antigen (PSA) test as a screening tool to reduce the overdiagnosis...
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CRISPR-based detection of SARS-CoV-2 RNA directly from patient swabs
In a recent study posted to Research Square*, researchers developed a clustered regularly interspaced short palindromic repeats (CRISPR)-based diagnostic technique for detecting severe acute respiratory...
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New study pinpoints how immune checkpoint protein LAG3 modulates T cell activity
Fighting cancer and chronic disease is tiring work for the immune system. When T cells are engaged in this kind of lengthy battle, they can...
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Monoclonal antibodies from COVID-19 convalescent donors target conserved site
In a recent study published on the bioRxiv* preprint server, researchers found six monoclonal antibodies (mAbs) binding to the spike (S) proteins of all human...
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Scientists discover differences in interaction of T-cells within tumor microenvironments
A team led by Northwestern Medicine investigators has discovered differences in the distribution and interaction of T-cells within the microenvironment of different regions of both...
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Orally delivered temperature-stable tablet vaccine efficacy against SARS-CoV-2 and other respiratory infections
In a recent article published in the Vaccines journal, researchers assessed the protective efficacy of temperature-stable orally delivered vaccines against respiratory viral pathogens. Study: Drop the Needle;...
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Exploring strategies for successful delivery of messenger RNA therapeutics
In a recent study published in the journal Materials Today Advances, researchers reviewed the material properties and administration routes that could successfully deliver a messenger...
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Mayo Clinic researchers devise a combination approach to more effectively target solid tumors
Researchers at Mayo Clinic’s Center for Individualized Medicine have devised an immunotherapy technique that combines chimeric antigen receptor-T cell therapy, or CAR-T cell therapy, with...
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Novel transdermal vaccine delivery for COVID-19 and cancer
Transdermal drug delivery is an alternative to oral or invasive drug delivery systems. This approach is associated with several advantages including its ability to bypass...
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Researchers identify certain gene regulation signatures in CAR T-resistant leukemia patients
Acute lymphoblastic leukemia (ALL) cells from patients whose cancers did not respond to CD19-targeted CAR T therapy had gene regulation signatures that could potentially facilitate...